Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints
نویسندگان
چکیده
منابع مشابه
Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints.
This article reviews the main molecular alterations involved in endometrial carcinoma. Five molecular features (microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and beta-catenin genes) are characteristic of endometrioid carcinomas, whereas non-endometrioid carcinomas show alterations of p53, loss of heterozygosity (LOH) on several chromosomes, as well as other molecular alte...
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Four different genetic abnormalities may occur in endometrioid adenocarcinomas of the endometrium (mircosatellite instability and mutations in the PTEN, k-RAS and beta-catenin genes), whereas nonendometrioid carcinomas of the endometrium often have p53 mutations and loss of heterozygosity on several chromosomes. Occasionally, a nonendometrioid carcinoma may develop as a result of dedifferentiat...
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Endometrial cancer is the most commonly diagnosed gynecological cancer and its incidence is increasing worldwide. The number of patients with this disease is likely to continue to grow, including younger patients. It is a complex disease driven by abnormal genetic and epigenetic alterations, as well as environmental factors. Many endometrial cancers show estrogen-dependent proliferation. The ca...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 2008
ISSN: 0021-9746
DOI: 10.1136/jcp.2008.056101